GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1056667 | 1 | rs4713008 | chr6:26538268 | BTN2A3 | chr6:26422317-26431927:+ | 0.18 | 4.32 | 1.87E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs4713008 | chr6:26538268 | HCG11 | chr6:26521934-26527610:+ | -0.22 | -4.34 | 1.77E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs4713008 | chr6:26538268 | HMGN4 | chr6:26538572-26547162:+ | -0.16 | -4.04 | 6.24E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs4713008 | chr6:26538268 | ZNF322A | chr6:26634612-26659963:- | -0.14 | -3.9 | 0.000108 | Educational attainment |
| THCA | cis | rs4713039 | 1 | rs4713039 | chr6:10906256 | SYCP2L | chr6:10747995-10974539:+ | -0.24 | -3.87 | 0.000126 | Allergic rhinitis |
| THCA | cis | rs751728 | 1 | rs4713682 | chr6:33757047 | LEMD2 | chr6:33738991-33756906:- | -0.31 | -7.07 | 5.54E-12 | Crohn's disease |
| THCA | cis | rs751728 | 1 | rs4713684 | chr6:33766488 | LEMD2 | chr6:33738991-33756906:- | -0.3 | -6.97 | 1.03E-11 | Crohn's disease |
| THCA | cis | rs9380516 | 1 | rs4713882 | chr6:35501370 | TULP1 | chr6:35465653-35480647:- | -0.27 | -3.76 | 0.000195 | Hepatitis C induced liver fibrosis |
| THCA | cis | rs1983891 | 1 | rs4714483 | chr6:41528214 | MDFI | chr6:41604930-41621981:+ | 0.18 | 5.24 | 2.37E-7 | Prostate cancer |
| THCA | cis | rs1983891 | 1 | rs4714485 | chr6:41536587 | MDFI | chr6:41604930-41621981:+ | 0.19 | 5.45 | 8.11E-8 | Prostate cancer |
| THCA | cis | rs1983891 | 1 | rs4714486 | chr6:41542417 | MDFI | chr6:41604930-41621981:+ | 0.19 | 5.58 | 4.11E-8 | Prostate cancer |
| THCA | cis | rs9349407 | 1 | rs4715025 | chr6:47483653 | CD2AP | chr6:47445525-47594994:+ | 0.13 | 3.42 | 0.000676 | Alzheimer's disease (late onset) |
| THCA | cis | rs9473555 | 1 | rs4715129 | chr6:49415043 | CENPQ | chr6:49431096-49460820:+ | -0.27 | -5.67 | 2.41E-8 | Folate pathway vitamin levels |
| THCA | cis | rs9473555 | 1 | rs4715129 | chr6:49415043 | MUT | chr6:49398994-49431031:- | 0.28 | 9.36 | 3.11E-19 | Folate pathway vitamin levels |
| THCA | cis | rs9473555 | 1 | rs4715130 | chr6:49416825 | CENPQ | chr6:49431096-49460820:+ | -0.27 | -5.65 | 2.7E-8 | Folate pathway vitamin levels |